natural supplement for breast cancer

Royal jelly is one of the best natural remedies for breast cancer

Natural remedies for breast cancer? Royal jelly is a natural supplement that prevents breast cancer and helps you reduce the size of the already formed malignancy.

Royal jelly is a natural product widely consumed in daily diets in numerous countries. It has various pharmacological properties, including antioxidative, anti‑inflammatory and antibiotic properties and our growing awareness that bee products (as part of other natural supplements) are healthy and recommended to anyone, have contributed to an increasing number of studies investigating its effects.

• In September 2017 a study made on mice, “The effect of royal jelly on the growth of breast cancer in mice” by Shuang Zhang et al., from China, studied the effect of royal jelly on 4T1‑bearing mice and showed the efficacy of royal jelly supplementation in diets.

What is 4T1?
4T1 mammary carcinoma is a transplantable tumor cell line that is highly tumorigenic and invasive and, unlike most tumor models, can spontaneously metastasize from the primary tumor in the mammary gland to multiple distant sites including lymph nodes, blood, liver, lung, brain, and bone. The 4T1 tumor has several characteristics that make it a suitable experimental animal model for human mammary cancer. (

What was the treatment?
The  4T1‑bearing mice were fed with royal jelly using either the prophylactic‑therapeutic method (PTRJ) or therapeutic method (TRJ).

1. The mice fed with royal jelly using Prophylactic‑Therapeutic Method:
– the weight of tumor was significantly reduced (royal jelly 0.5 and 1.5 g/kg);
– in the serum, the levels of interleukin (IL)‑2 (royal jelly (RJ) 0.5 and 1.5 g/kg), interferon (IFN)‑α, superoxide dismutase (SOD) and total antioxidant capacity (T‑AOC) were significantly elevated, but the concentrations of IL‑4 (RJ 0.5 and 1.5 g/kg) and IL‑10 (RJ 1.0 g/kg) were significantly decreased.
– in the liver the activities of T‑AOC and glutathione reductase (GR) were significantly improved,
– in the kidney the activities of T‑AOC and GR were significantly increased only under the dose of 0.5 g/kg.

2. The mice fed with royal jelly using Therapeutic Method:
– the antitumor effect of RJ was not significant;
– the change in IL‑2, IFN‑α, SOD and T‑AOC levels in the serum, and the change in T‑AOC and GR in liver were similar to those observed in the PTRJ groups.

Royal jelly treatment was demonstrated to reduce the development of breast tumor in mice, and simultaneously improve the antioxidant capacity of the serum, liver and kidney, particularly using the prophylactic‑therapeutic method.

Royal jelly supplementation in diets reduces breast tumor weight!

Mako NAKAYA et al from Japan, showed in a 2014 study the “Effect of Royal Jelly on Bisphenol A-Induced Proliferation of Human Breast Cancer Cells“.
Bisphenol A is an environmental estrogen that enhances the proliferation of MCF-7 mammary cancer cells. Royal jelly inhibited the growth-promoting effect of BPA on MCF-7 cells, even though it did not affect the proliferation of cells in the absence of BPA. In addition, this inhibiting effect of royal jelly was heat-stable.

! I need to remind you that Bisphenol A is released from plastic containers at temperatures higher than 40°C (104°F).  It’s a common problem with bottled water in summer when supermarkets do not bother to keep the water in cold rooms (maybe due to lack of them) or when it is shipped during hot days.
It is recommended to drink water (or any other beverages) kept in glass containers. Giving up on plastic pets not only helps our health, but protects the planet as well.

• The study “Honey-bee products in prevention and/or therapy of murine transplantable tumours.” by Oršolić N et al. showed that royal jelly exhibited no significant effects on the formation of metastases in spontaneous mammary carcinoma of CBA mice when it was given intraperitoneally or subcutaneously. However, when royal jelly and tumor cells were injected synchronously into mice, royal jelly was able to inhibit the formation of metastases in the lung.

For cervico-uterine cancer
Fraction RJP30, a substance obtained from royal jelly crude protein, which was extracted by precipitation with 30% ammonium sulfate, demonstrated to be cytotoxic for HeLa human cervicouterine carcinoma cells, diminishing 2.5-fold the initial carcinoma cell density after 7 days of treatment (L.A.Salazar-Olivo, 2005).

Estrogens play a critical role in the development of breast cancer.

Royal jelly mimics human estrogens.
Adding it in your diets prevents and fights against breast cancer! 

Royal jelly is a substance for ladies. From lady-bees to lady-humans. It is a thick and milky liquid secreted by hypopharyngeal and mandibular glands of young worker bees (Apismellifera L.) used to feed the larvae in their first 3 days and the queen for the rest of her life. A sort of “colostrum” of mammals if you want. The food of newborns.

Estrogen is the primary female sex hormone. It is responsible for the development and regulation of the female reproductive system and secondary sex characteristics. But the term “estrogen” refers to all of the chemically similar hormones in this group, which are estrone, estradiol (primary in women of reproductive age) and estriol.

In 2007, a study done in Japan showed that royal jelly has the propensity to mimic human estrogen, thus helping people with low estrogen levels.  (read Royal jelly and fertility)

• The 2005 study Royal jelly has estrogenic effects in vitro and in vivo, by Mishima S et al from Japan, showed that royal jelly has estrogenic activities through interaction with estrogen receptors followed by endogenous gene expressions.

As the research team explains “Treatment with royal jelly at concentrations ranging from 0.5 to 1 mg/ml enhanced MCF-7 cell proliferation, but concomitant treatment with 1 microM tamoxifen blocked this effect. In vivo studies using ovariectomized rats showed that 17beta-estradiol (20 mg/kg, s.c.) treatment restored VEGF expression in both uterus and brain, whereas royal jelyy (1 g/kg, s.c.) restored it in uterus but not in brain.”

read What is royal jelly good for and how to take it.

It was identified that royal jelly stimulated the expression of endogenous estrogen-responsive genes [presenilin 2 and vascular endothelial growth factor (VEGF)] by activating estrogen receptors in MCF-7 cells, and royal jelly could restore the expression of VEGF in uterus of rats that received bilateral ovariectomy.

• “Estrogenic activities of Fatty acids and a sterol isolated from royal jelly.” by Suzuki KM et al, Japan, published experimental results which demonstrated that four compounds from royal jelly can improve the transcription of a reporter gene, which contained an estrogen-responsive element, and subcutaneously injecting immature rats with those compounds for 23 days induced mild hypertrophy in the luminal epithelium of the rat uterus.

• Althuis MD et al in the study Etiology of hormone receptor-defined breast cancer: a systematic review of the literature, summarized that with evidence that it was an etiological cause of breast cancer, estrogen attracted numerous studies on its association with breast carcinogenesis.

Estrogen metabolism and breast cancer, the article signed by Samavat and Kurzer in 2015, evaluated the roles and metabolites of circulating, and urinary estrogens in human breast cancer. According to them endogenous estrogens play a critical role in the development of breast cancer. In this review they describe in detail estrogen metabolism and associated genetic variations, and provide a critical review of the current literature regarding the role of estrogens and their metabolites in breast cancer risk.

Treatment strategy for metastatic breast cancer with estrogen receptor-positive tumor, have been researched by Hirotaka Iwase, Japan. Endocrine therapy is regarded as one of the earliest molecular-targeting therapies applied in breast cancer treatment.

Breast cancer is associated with high morbidity and mortality rates among women in developed and developing countries. However, according to science in this point, the effect of royal jelly on mammary cancer cells remains unclear. By now the findings are encouraging, but there is still need for a detailed and comprehensive study on the effect of royal jelly on breast cancer, which may aid in understanding the association between royal jelly and breast cancer.

Effects of royal jelly on other types of cancer:

On colorectal cancer:
10-HDA (ie 10-hydroxy acid 2-decenoic), a compound of royal jelly, has shown exceptional effects of preventing and treating cancer. This 10-DHA prevents the vascularization of tumors, thus preventing their proliferation and growth.

• A study by Filipič B et al. from 2015 investigated the influence of royal jelly, its bioactive component 10-hydroxy-2-decenoic acid (10- HDA), and human interferon-alpha (HuIFN-αN3) on the proliferation of human colorectal adenocarcinoma cells (CaCo- 2), and ascertain their effect on intracellular glutathione (GSH) level and lipid peroxidation. The results showed that royal jelly and HuIFN-αN3 applied at 2:1 decreased the level of GSH the most and significantly increased lipid peroxidation via MDA in CaCo-2 cells.

• The study from 2017, Royal jelly lipophilic fraction induces antiproliferative effects on SH-SY5Y human neuroblastoma cells, by Gismondi A et al from Italy proved the  by the “extraordinary antiproliferative activity of the lipophilic extract of all royal jelly against SH-SY5Y cells, suggesting a potential medical application of this bee product to prevent the onset and slow down the growth of human neuroblastoma.”


Traditional medicine, based on experience alone, without the need of all these research, recommends 1 to 3 courses of treatment per year, lasting for 60 days, with 1 gram of fresh royal jelly per day. During this period keep a vegetarian diet, in order to make a favorable background for the anti-tumor action of this substance.

Find royal jelly on Amazon

It has to be fresh, it’s the form that preserves all its healthy compounds. Be sure you have first read all about Contraindications and side-effects of royal jelly and how to take it. sells fresh royal jelly and the products have very good reviews. Worth trying. has different products, but equally qualitative, with free UK shipping:

This is not honey and it will taste nothing like it. It has a bitter taste and a strong odor and you’ll have to take it first thing in the morning. But you won’t be sorry!

Trust royal jelly. Supplement your diets with it!

It is antioxidant, immunoregulatory, antifungal, antibiotical, erythropoietic, hypoglycemic, anticholesteremic, antithyroidic, anti-osteoporotic and estrogenic properties. I think I haven’t forgotten anything… 🙂

further readings:

What supplements lower cholesterol and normalize blood pressure

◘ Can royal jelly be an efficient natural treatment for lupus?

◘ Royal jelly is an efficient natural treatment for diabetes type 2.

◘ Royal Jelly health benefits

Other references:



Laura Bujor

Laura Bujor is the author and founder of She built this website as a personal journey to discover the power of honey and share it with the world. She learned directly from beekeepers and took a course in apitherapy. From a hobby, honey and apitherapy turned into a professional career. You can find her on LinkedIn, Facebook, Pinterest and X.

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